College Football Odds, Picks and Predictions for Week 2, 2022: Proven Model Supporting Pittsburgh, Iowa State

College Football Odds, Picks and Predictions for Week 2, 2022: Proven Model Supporting Pittsburgh, Iowa State

After Week 1 ran Thursday through Monday over Labor Day weekend, the Week 2 college football schedule is more condensed. There are two games — Louisville vs. UCF and Boise State vs. New Mexico — on Friday, followed by a full slate on Saturday. Caesars Sportsbook’s latest Week 2 college football odds list the Knights at -6.5 and the Broncos at -16.5 in the Friday night kickoff. One of the headliners on Saturday’s slate is Alabama taking on Texas, and the Week 2 college football lines show the Crimson Tide at -20 in this one.

Other intriguing matchups include Appalachian State vs. Texas A&M (-17), Tennessee vs. Pittsburgh (+7), Kentucky vs. Florida (-4.5), and Baylor vs. BYU (-3.5). What spreads, totals and money lines should you target in your best college football bets this week? Before you lock in the Week 2 college football picks for these games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated an astonishing profit of nearly $3,500 for $100 players on its top-rated college football picks against the spread. He enters Week 2 of the 2022 college football season on a 48-37 run on all college football and money-line top picks that dates back to 2021. Everyone who has followed him has seen huge returns.

Now, he’s turned his attention to Caesars’ latest Week 2 college football odds and locked in picks for every FBS game. Head here to see each choice.

Best College Football Predictions for Week 2

One of the college picks the model is high on in Week 2: Pittsburgh covers as a 7-point home underdog against Tennessee in a game at 3:30 p.m. ET Saturday. Pitt won 41-34 at Knoxville in the first half of this home-and-away series last year. The Vols return a lot of firepower on offense, and Pitt’s loss of Kenny Pickett is a big reason Tennessee is favored in this one, despite being on the road.

USC transfer Kedon Slovis looks like a suitable replacement after guiding the Panthers to a win over West Virginia in the Backyard Brawl last week. The Vols weren’t tested that far in a laugh-out against Ball State.

SportsLine’s model projects Tennessee to take the narrow victory, but points are extremely valuable in what could very well be a close game. The Panthers stay in the numbers well over 50% of the time, making them one of the teams to back in your Week 2 college football bets.

Another prediction: Iowa State (+3.5) stays in the gap on the road against Iowa at 4 p.m. ET in the 2022 Cy-Hawk game. The Hawkeyes picked up one of the ugliest wins of Week 1 when they thrashed FCS South Dakota State with a 7-3 victory. Iowa gained just 166 total yards, had two turnovers and needed two second-half safeties to secure a four-point victory.

On the other hand, Iowa State performed as expected against another FCS school in Southeast Missouri State with a 42-10 victory. QB Hunter Dekkers had nearly 300 yards and four passing touchdowns while the rushing offense – led by Jirehl Brock’s 104 yards – had 176 yards that day.

That kind of balance will keep the Cyclones in the game, especially against an offense that has struggled so much with less competition. The Cyclones should rush nearly 200 yards on offense and limit Iowa to just 100 yards on the ground with their defense. SportsLine’s model indicates that Iowa State covers well over 50% of simulations. See what other teams the model likes here.

How to Make College Football Picks for Week 2

The model also called for who wins and covers in all of the other Week 2 FBS matchups, and that calls for several outright upsets. You can only get every pick for every game on SportsLine.

So what college football picks can you make with confidence? And which favorites will fall hard? Check out the latest college football odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a proven computer model that has returned nearly $3,500 in profit over the past six months. seasons and more, and find out.

College football odds for week 2 (via Caesars)

See the full Week 2 college football picks, odds and predictions here.

Friday, September 9

Louisville at UCF (-6.5, 61.5)

Featured game | UCF Knights vs. Louisville Cardinals

Boise State vs. New Mexico (+17.5, 46.5)

Featured game | New Mexico Lobos vs. Boise State Broncos

Saturday September 10

Alabama at Texas (+20.5, 61.5)

Featured game | Texas Longhorns vs. Alabama Crimson Tide

South Carolina at Arkansas (-7.5, 52.5)

Featured game | Arkansas Razorbacks vs. South Carolina Gamecocks

Arkansas State at Ohio State (-43.5, 68.5)

Tennessee at Pittsburgh (+7, 65.5)

Featured game | Pittsburgh Panthers vs. Tennessee Volunteers

Iowa State at Iowa (-3.5, 41.5)

Featured game | Iowa Hawkeyes vs. Iowa State Cyclones

Virginia at Illinois (-4.5, 54)

Featured game | Illinois Fighting Illini vs. Virginia Cavaliers

Kentucky at Florida (-5, 51.5)

Featured game | Florida Gators vs. Kentucky Wildcats

Arizona State at Oklahoma State (-11, 54.5)

Featured game | Oklahoma State Cowboys vs. Arizona State Sun Devils

USC at Stanford (+9, 65.5)

Featured game | Stanford Cardinal vs. USC Trojans

Baylor at BYU (-3, 53.5)

Featured game | BYU Cougars vs. Baylor Bears


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